Kim N. Ha

Assistant Professor

651-690-8617

knha@stkate.edu

Ph.D., Biochemistry
University of Minnesota, Minneapolis, Minnesota, 2012

Master of Science, Chemistry
University of Minnesota, Minneapolis, Minnesota, 2007

Bachelor of Arts, Chemistry
University of Minnesota, Minneapolis, Minnesota, 2004

Minnesota Medical Foundation. (2012). Dr. Marvin and Hassedeh Bacaner Award for creativity in biomedical research

Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Ross A. Gortner Award for excellence in protein chemistry and enzymology research.

Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Beatrice Z. Milne and Theodore Brandenburg Award for Excellence in Graduate Thesis Research

Department of Biochemistry, Molecular Biology, and Biophysics - University of Minnesota. (2011). Cyrus Barnum Teaching Award

College of Biological Sciences - University of Minnesota. (2011). Teaching Assistant of the Year Award, Finalist

National Heart Lung and Blood Institute, NIH. (2008). Ruth Kirschstein National Research Service Award Predoctoral Fellowship

Academic Professional Development Committee Research Award. Project: “Characterizing Dynamics-Driven Ligand Selection of Adipocyte Fatty Acid Binding Protein” (2017)

Clare Booth Luce Collaborative Research Mentor. Project: “Characterization of Dilated Cardiomyopathy Linked R25 Mutations of Phospholamban” (2016-2017)

Summer Scholars Program. Project: “NMR Resonance Assignment of Fatty Acid Binding Protein-4” (2014)

Academic Professional Development Committee Curriculum Development Award. Project: “Development of the Advanced Biochemistry Course: Biochemistry II” (2014)

Large 3M Collaborative Research Grant. Project: “Pushing the limits of rational design in therapeutic phospholamban mutants through optimizing dephosphorylation by protein-phosphatase 1” (2014)

National Science Foundation, Co-PI. Project: “Phase Forward: Turning Obstacles into Opportunities” (2012-2016)

Clare Booth Luce Collaborative Research Mentor. Project: “Dephosphorylation on Therapeutic Mutants of the Cardiac Protein Phospholamban” (2013-2014)

National Heart Lung and Blood Institute, National Institutes of Health (1F31HL095361-01) Project: “Rational Design of Loss-of- Function Phospholamban Mutants for Gene Therapy” (2009-2012)

Assistant Professor, St. Catherine University, 2012–Present

Lab Manager, BMBB University of Minnesota, 2010-2012

Post Doctoral Associate, BMMB University of Minnesota, 2012

Graduate Research Assistant, University of Minnesota, 2004-2012

Journal Articles

Vostrikov, V.V., Soller, K.J., Ha, K.N., Gopinath, T., Veglia, G. (2015) “Effects of Naturally Occuring Arginine 14 Deletion on Phospholamban Conformational Dynamics and Membrane Interactions.” Biochimica Biophys Acta. 1848(1 Pt B):315-22

Ha, K.N., Gustavsson, M., Veglia, G. (2012) “Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control SERCA inhibition.” Journal of Muscle Research and Cell Motility. 33(6):485-92

Ha, K.N., Masterson, L.R., Hou, Z., Verardi, R., Menard, N., Robia, S.L., Veglia, G. (2011) “A mutation associated with dilated cardiomyopathy increases phospholamban (PLN) oligomerization and decreases SERCA-binding.” Proceedings of the National Academy of Sciences U S A. 108(7):2735-40.

Masterson, L.R., Bortone, N., Yu, T., Ha, K.N., Gaffarogullari, E.C., Nguyen, O., Veglia, G. (2009) “Expression and purification of isotopically labeled peptide inhibitors and substrates of cAMP-dependant protein kinase A for NMR analysis.” Protein Expression and Purification. 64(2):231-6.

Ha, K.N., Traaseth, N.J., Verardi, R., Zamoon, J., Cembran, A., Karim, C.B., Thomas, D.D., Veglia, G. (2007) “Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics.” J. Biol. Chem. 282(51):37205-14

Reviews

Traaseth, N.J., Ha, K.N., Verardi, R., Shi, L., Buffy, J.J., Veglia, G. (2008) “Structural and Dynamic Basis of Phospholamban and Sarcolipin Inhibition of Ca2+-ATPase (SERCA).” Biochemistry. 47(1):3-13.

Book Chapters

Veglia, G., Ha, K.N., Traaseth, N.J., Verardi, R., Shi, L. (2010) “What Can We Learn from Small Membrane Proteins?” Methods in Molecular Biology 654:303-19.

Dissertation/Thesis

Ha, K.N. (2012). "Rational Design of loss-of- function phospholamban mutants to tune SERCA function."

Invited Seminars

“Utilizing structural dynamics-function based protein design to innovate new approaches in treating cardiomyopathies and diabetes.” Department of Chemistry and Biochemistry Seminar, University of Minnesota Duluth. October 23, 2015.

Poster Presentations

“Characterization of dilated cardiomyopathy linked R25 mutants of phospholamban.” Mara H. Exline, Kim N. Ha. National Meeting of the American Chemical Society. San Francisco, CA. April 1-5, 2017.

“Building a better phospholamban: characterizing and optimizing the structural dynamics of domain Ib PLN mutants to tune SERCA function” Kim N. Ha, Mara H. Exline, Sarah E. Nelson, Gianluigi Veglia. Keystone Symposia: RNA Based Approaches in Cardiovascular Disease. Keystone CO. March 27-31, 2017.

“Building a better phospholamban: characterizing and optimizing the structural dynamics of domain Ib PLN mutants to tune SERCA function” Kim N. Ha, Mara H. Exline, Sarah E. Nelson, Gianluigi Veglia. Biophysical Society Meeting. New Orleans, LO. February 11-15, 2017.

“Elucidating the role of structural dynamics in ligand selection of human adipocyte fatty acid binding protein by NMR spectroscopy.” Kim N. Ha, Youlin Xia, Yenchi Tran, Gianluigi Veglia, David A. Bernlohr. Biophysical Society Meeting. Los Angeles, CA. February 27-March 2nd, 2016.

“Investigating the structural dynamics transitions of human adipocyte fatty acid binding protein by NMR spectroscopy.” Kim N Ha, Youlin Xia, Yenchi Tran, Adedolapo Ojoawo, Gianluigi Veglia, David Bernlohr. Biophysical Society Meeting. Baltimore, MD. February 7-11, 2015.

“Investigating the structural dynamics transitions of human adipocyte fatty acid binding protein by NMR spectroscopy.” Kim N Ha, Youlin Xia, Yenchi Tran, Adedolapo Ojoawo, Gianluigi Veglia, David Bernlohr. 249th ACS National Meeting & Exposition. Denver, CO. March 22-26 2015.

“Rational Structure-based Design of PLN Mutants to Optimize Dephosphorylation and Tune SERCA Function.” Choua Xiong, Adedolapo Ojoawo, Kim N. Ha. Biophysical Society Meeting. San Francisco, CA. February 15-19, 2014.

“Structural Dynamics Studies of Fatty Acid Binding Protein-4 by Solution NMR Spectroscopy.” Adedolapo Ojoawo, Choua Xiong, Kim N. Ha. Biophysical Society Meeting. San Francisco, CA. February 15-19, 2014.

“Rational Structure-Based Design of PLN Mutants to Tune SERCA Function.” Kim N. Ha, Martin Gustavsson, Raffaello Verardi, Gianluigi Veglia. FASEB Summer Research Conference: Molecular Biophysics of Membranes. Steamboat Springs, CO June 17 – 22, 2012.